abril 2024
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Retinitis Pigmentosa (RP) is a group of inherited, progressive, retinal degenerative diseases. In Spain, 15.000 people are affected by RP and 480.000 have one or more of the different genes responsibles for the disease. RP is the major cause of blindness in young adults and there is no treatment or therapy. Then, research in this field is essential.
RP shows different genotypes and phenotypes and the visual outcome varies between different subtypes as well as between members of the same family. The most complete knowledge about the morphological and functional alterations of the retina of RP patients is essential to select for each RP patient the most suitable regenerative therapy from those now under research.
The aim of the investigation is precisely to study, with the most advanced morphological and functional now available techniques, the retina of RP patients and to classify them according to their alterations.
The specific objectives of our research are:
- To determine in detail the electrophysiological characteristics of the retina and visual cortex of RP patients by stimulating and recording 61 areas of the retina by ERGmf.
- To determine the morphological characteristics of the different retinal layers of RP patients by optical coherent Tomography (OCT).
- To determine deficits in attention and perception of visual stimuli that vary in contrast and eccentricity in the visual field with the method TEPECA, developed in our Laboratory
- On the basis of the results of previous objectives, to generate a data base of retinal and perceptive properties of each RP patient.
- To improve visual perception of RP patients by home daily visual training with the web plattaform VistaTraining, developed in our Laboratory of Visual and Cognitive Neuroscience (http//vistatraining.es).